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KMID : 0370019950090000111
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Chung-Ang Journal of Pharmacal Sciences
1995 Volume.9 No. 0 p.111 ~ p.122
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Comparison of Iiposome-incorporated antibiotics and free drugs in inhibition of L. pneumophila multiplication within U937, human monocyte-like cell line
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Abstract
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The facultative intracellular pathogen, legionella pneumophila, multiplies within and kills human blood monocytes and alveolar macrophages. The therapeatic efficacies of liposome-incorporated antibiotics against L. pneumophila were evaluated in a model of intracellular infection. β-lactams are very effective(ampicillin MIC=0.63㎍/㎖) in vitro against L. pneumophila, but clinically are not useful. It´s mainly because of their poor penetration properties into cells. Liposome-incorporation is an useful delivery method for antibiotics to macrophages and monocytes. In this experiment phospholipid was composed of DMPC : CHOL : DCP=7 : 1 : 2 molar ratio. Compared with free form (MIEC=36㎍/㎖) against intracellular L. pneumophila. And Ciprofloxacin also showed improvement (about 8 times less MIEC).
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KEYWORD
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